Queen's Gambit is a fictional story that follows the life of an orphaned chess prodigy Beth Harmon (Anya Taylor-Joy) in her quest to become the world's greatest chess player while struggling with emotional issues and drug and alcohol addiction. The story begins in the mid 1950s and continues into the 1960s. 
The series begins at a girls' orphanage where nine-year-old Beth lost her mother in a car accident, with Jolene (Moses Ingram), an energetic and friendly girl a few years older than her, Helen Deardorff (Christiane Seidel), who runs the orphanage, and Beth's first chess lesson. Mr. Shaibel (Bill Camp), guardian of the teaching Orphanage. As was common in the 1950s,  the orphanage distributes daily sedative pills to girls, which turned into an addiction for Beth. A few years later, Beth Alma Wheatley (Marielle Heller) and Lexington are adopted by her husband from Kentucky. After being adopted and adjusting to his new home, Beth enrolls in chess tournaments, despite having no previous experience. He wins many games and is eventually noticed by others and develops friendships with a few others, including former Kentucky State champion Harry Beltik (Harry Melling), chess scientist Benny Watts (Thomas Brodie-Sangster), and Townes (Jacob Fortune-Lloyd). As Beth continues to win games and reap the financial benefits of her success, she becomes more addicted to drugs and alcohol and begins to lose control of her life.
Still, he eventually beat the Russian chess world champion in Moscow in a spectacular game in which the Queen's Gambit opening was actually played.